Tracking Truth: Knowledge, Evidence, and Science


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Sorry not to be in regular blogging mode at the moment. I think clinical trials are the best possible way to approach this issue. With clinical trials you can make clear rules, you can measure compliance, and you can enforce compliance. Regular readers will be familiar with this ongoing battle. In medicine we use the results of clinical trials to make informed treatments about which treatments work best; but the results of clinical trials are being routinely and legally withheld from doctors, researchers, and patients.

This is a problem for industry sponsored trials, and for trials funded by governments and charities. So what did we find? The results on the individual companies are important, but we also came across some fascinating patterns.

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While companies superficially have commitments to register and report clinical trials, in reality, there are often huge gaps in their policies, with many failing to include past trials trials on the medicines we use today and trials on off-label uses or unlicensed medicines, which are both important. Lastly, as we went along we collected some fascinating examples of problematic policies, ambiguous language, inconsistent commitments, odd exclusions, and so on. Overall this audit was a huge project, and we hope it will be widely used.

2. Lightweight Knowledge

You can see which companies are the best, and the worst. The full methods and results can be read, for free, in the paper. Coming next, we have ranked the policies of non-industry trial funders, and that paper will land shortly. We also have some great new and improved projects launching soon where we track the performance of institutions, rather than their promises: the proportion of their completed trials for which they have shared results.

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By now I hope you all know about the ongoing global scandal of clinical trial results being left unpublished, and of course our AllTrials campaign.

Tracking Truth: Knowledge, Evidence, and Science Tracking Truth: Knowledge, Evidence, and Science
Tracking Truth: Knowledge, Evidence, and Science Tracking Truth: Knowledge, Evidence, and Science
Tracking Truth: Knowledge, Evidence, and Science Tracking Truth: Knowledge, Evidence, and Science
Tracking Truth: Knowledge, Evidence, and Science Tracking Truth: Knowledge, Evidence, and Science
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