Despite all this, sperm with fragmented DNA can be fertile, and the biological impact of an abnormal sperm chromatin structure depends on the combined effects of the extent of DNA or chromatin damage in the sperm and the capacity of the oocyte to repair that damage 3539 - From a clinical perspective, sperm DNA damage, including chromatin fragmentation, has been associated with impaired spermatogenesis and infertility and can have negative consequences on the reproductive process 43 - 46including recurrent pregnancy loss RPL Various studies have investigated the relationship between sperm DNA damage and reproductive outcome.
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